Such activity requires the concurrent secretion of large amounts of Ca 2+-carrying/transporting proteins acting as a micro-conveyor belt system inside the RER–Golgi. From a reinterpretation of some classical and recent data gained mainly, but not exclusively, from (insect) endocrinology, the view emerged that the likely primordial function of the rough endoplasmic reticulum (RER)–Golgi complex in all eukaryotes was not the secretion of any type of protein but the removal of toxic excess Ca 2+ from the cytoplasm. Neither does it specify which functional requirements the secreted proteins must meet. The extensive literature dealing with the Golgi system emphasizes its role in protein secretion and modification, usually without specifying from which evolutionary ancient cell physiological necessity such secretion originated. Research Group of Functional Genomics and Proteomics, Department of Biology, KU Leuven, Leuven, Belgium.Function(s) of Farnesol/Farnesol-Like Sesquiterpenoids in the Golgi Membranes.The Golgi Apparatus as a Probable Subcellular Site of Synthesis of Farnesol/Farnesol-Like Sesquiterpenoid: Origin of This Idea.A Still Continuing Search: How Many Sites of Farnesol/Farnesol-Like Sesquiterpenoid Synthesis Are in the Body?.
Always Keep in Mind That There Is No “Goal” in Evolution, Only “Physiological Necessity”.The editor and reviewers' affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review. Confederation of Industry of the Czech Republic, Czechia
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